Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library
Identifieur interne : 002C67 ( Main/Exploration ); précédent : 002C66; suivant : 002C68Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library
Auteurs : John Sidney [États-Unis] ; Bjoern Peters [États-Unis] ; Carrie Moore [États-Unis] ; Timothy J. Pencille [États-Unis] ; Sandy Ngo [États-Unis] ; Kelly-Anne Masterman [États-Unis] ; Shinichi Asabe [États-Unis] ; Clemencia Pinilla [États-Unis] ; Francis V. Chisari [États-Unis] ; Alesandro Sette [États-Unis]Source :
- Immunogenetics [ 0093-7711 ] ; 2007-09-01.
English descriptors
Abstract
Abstract: Chimpanzees represent important models for studying several human pathogens. In the present study, we utilized a combinatorial peptide library to characterize the binding specificities of the chimpanzee class I molecules Patr A*0301 and A*0401, both of which are present in about 17% of chimpanzees. Patr A*0301 was found to recognize peptides using the canonical position 2/C-terminus spacing, with the small residues S, T, and A being the most preferred in position 2, and the positively charged residues R and K preferred at the C terminus. Patr A*0401 was found to recognize a more complex motif where the C terminus and then the residue in positions 1 and/or 5 are the primary anchors. Like A*0301, the C-terminal preference of A*0401 is for positively charged residues. At positions 1 and 5, positively charged and large residues are the most preferred, respectively. Coefficient values derived from the combinatorial library proved to be an efficient means for predicting A*0301 and A*0401 binders. The present data provide detailed information to facilitate the identification of potential T cell epitopes recognized in the context of two common chimpanzee class I alleles, and further validate the combinatorial library approach as an efficient method to characterize class I binding specificities.
Url:
DOI: 10.1007/s00251-007-0243-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000168
- to stream Istex, to step Curation: 000168
- to stream Istex, to step Checkpoint: 000920
- to stream Main, to step Merge: 002C93
- to stream Main, to step Curation: 002C67
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library</title>
<author><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
</author>
<author><name sortKey="Moore, Carrie" sort="Moore, Carrie" uniqKey="Moore C" first="Carrie" last="Moore">Carrie Moore</name>
</author>
<author><name sortKey="Pencille, Timothy J" sort="Pencille, Timothy J" uniqKey="Pencille T" first="Timothy J." last="Pencille">Timothy J. Pencille</name>
</author>
<author><name sortKey="Ngo, Sandy" sort="Ngo, Sandy" uniqKey="Ngo S" first="Sandy" last="Ngo">Sandy Ngo</name>
</author>
<author><name sortKey="Masterman, Kelly Anne" sort="Masterman, Kelly Anne" uniqKey="Masterman K" first="Kelly-Anne" last="Masterman">Kelly-Anne Masterman</name>
</author>
<author><name sortKey="Asabe, Shinichi" sort="Asabe, Shinichi" uniqKey="Asabe S" first="Shinichi" last="Asabe">Shinichi Asabe</name>
</author>
<author><name sortKey="Pinilla, Clemencia" sort="Pinilla, Clemencia" uniqKey="Pinilla C" first="Clemencia" last="Pinilla">Clemencia Pinilla</name>
</author>
<author><name sortKey="Chisari, Francis V" sort="Chisari, Francis V" uniqKey="Chisari F" first="Francis V." last="Chisari">Francis V. Chisari</name>
</author>
<author><name sortKey="Sette, Alesandro" sort="Sette, Alesandro" uniqKey="Sette A" first="Alesandro" last="Sette">Alesandro Sette</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5994DEE879EEAD6FDC4DD0C23C79F8DE217192C3</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1007/s00251-007-0243-5</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-5HBP8NPS-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000168</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000168</idno>
<idno type="wicri:Area/Istex/Curation">000168</idno>
<idno type="wicri:Area/Istex/Checkpoint">000920</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000920</idno>
<idno type="wicri:doubleKey">0093-7711:2007:Sidney J:characterization:of:the</idno>
<idno type="wicri:Area/Main/Merge">002C93</idno>
<idno type="wicri:Area/Main/Curation">002C67</idno>
<idno type="wicri:Area/Main/Exploration">002C67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library</title>
<author><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moore, Carrie" sort="Moore, Carrie" uniqKey="Moore C" first="Carrie" last="Moore">Carrie Moore</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pencille, Timothy J" sort="Pencille, Timothy J" uniqKey="Pencille T" first="Timothy J." last="Pencille">Timothy J. Pencille</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ngo, Sandy" sort="Ngo, Sandy" uniqKey="Ngo S" first="Sandy" last="Ngo">Sandy Ngo</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Masterman, Kelly Anne" sort="Masterman, Kelly Anne" uniqKey="Masterman K" first="Kelly-Anne" last="Masterman">Kelly-Anne Masterman</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Scripps Research Institute, 10550 North Torrey Pines Rd., 92037, San Diego, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Asabe, Shinichi" sort="Asabe, Shinichi" uniqKey="Asabe S" first="Shinichi" last="Asabe">Shinichi Asabe</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Scripps Research Institute, 10550 North Torrey Pines Rd., 92037, San Diego, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pinilla, Clemencia" sort="Pinilla, Clemencia" uniqKey="Pinilla C" first="Clemencia" last="Pinilla">Clemencia Pinilla</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, 2-129, 92121, San Diego, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chisari, Francis V" sort="Chisari, Francis V" uniqKey="Chisari F" first="Francis V." last="Chisari">Francis V. Chisari</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Scripps Research Institute, 10550 North Torrey Pines Rd., 92037, San Diego, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sette, Alesandro" sort="Sette, Alesandro" uniqKey="Sette A" first="Alesandro" last="Sette">Alesandro Sette</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, 92037, La Jolla, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Immunogenetics</title>
<title level="j" type="abbrev">Immunogenetics</title>
<idno type="ISSN">0093-7711</idno>
<idno type="eISSN">1432-1211</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="2007-09-01">2007-09-01</date>
<biblScope unit="volume">59</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="745">745</biblScope>
<biblScope unit="page" to="751">751</biblScope>
</imprint>
<idno type="ISSN">0093-7711</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0093-7711</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen presentation</term>
<term>Epitopes</term>
<term>Major histocompatibility complex</term>
<term>Pan troglogdytes</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Chimpanzees represent important models for studying several human pathogens. In the present study, we utilized a combinatorial peptide library to characterize the binding specificities of the chimpanzee class I molecules Patr A*0301 and A*0401, both of which are present in about 17% of chimpanzees. Patr A*0301 was found to recognize peptides using the canonical position 2/C-terminus spacing, with the small residues S, T, and A being the most preferred in position 2, and the positively charged residues R and K preferred at the C terminus. Patr A*0401 was found to recognize a more complex motif where the C terminus and then the residue in positions 1 and/or 5 are the primary anchors. Like A*0301, the C-terminal preference of A*0401 is for positively charged residues. At positions 1 and 5, positively charged and large residues are the most preferred, respectively. Coefficient values derived from the combinatorial library proved to be an efficient means for predicting A*0301 and A*0401 binders. The present data provide detailed information to facilitate the identification of potential T cell epitopes recognized in the context of two common chimpanzee class I alleles, and further validate the combinatorial library approach as an efficient method to characterize class I binding specificities.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
</noRegion>
<name sortKey="Asabe, Shinichi" sort="Asabe, Shinichi" uniqKey="Asabe S" first="Shinichi" last="Asabe">Shinichi Asabe</name>
<name sortKey="Chisari, Francis V" sort="Chisari, Francis V" uniqKey="Chisari F" first="Francis V." last="Chisari">Francis V. Chisari</name>
<name sortKey="Masterman, Kelly Anne" sort="Masterman, Kelly Anne" uniqKey="Masterman K" first="Kelly-Anne" last="Masterman">Kelly-Anne Masterman</name>
<name sortKey="Moore, Carrie" sort="Moore, Carrie" uniqKey="Moore C" first="Carrie" last="Moore">Carrie Moore</name>
<name sortKey="Ngo, Sandy" sort="Ngo, Sandy" uniqKey="Ngo S" first="Sandy" last="Ngo">Sandy Ngo</name>
<name sortKey="Pencille, Timothy J" sort="Pencille, Timothy J" uniqKey="Pencille T" first="Timothy J." last="Pencille">Timothy J. Pencille</name>
<name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<name sortKey="Pinilla, Clemencia" sort="Pinilla, Clemencia" uniqKey="Pinilla C" first="Clemencia" last="Pinilla">Clemencia Pinilla</name>
<name sortKey="Sette, Alesandro" sort="Sette, Alesandro" uniqKey="Sette A" first="Alesandro" last="Sette">Alesandro Sette</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5994DEE879EEAD6FDC4DD0C23C79F8DE217192C3 |texte= Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library }}
This area was generated with Dilib version V0.6.33. |